A 60-year-old presents with pruritus, night sweats, and enlarged supraclavicular nodes. What do you suspect?

The symptoms presented by the 60-year-old patient—pruritus, night sweats, and enlarged supraclavicular nodes—are classic indicators of Hodgkin lymphoma. This condition is characterized by the presence of Reed-Sternberg cells, which can lead to systemic symptoms such as fever, night sweats, and weight loss, often referred to as "B symptoms."

Pruritus is particularly associated with Hodgkin lymphoma, where patients frequently report severe itching, which can be distressing. The involvement of supraclavicular lymph nodes points toward lymphoma as a likely diagnosis, as these nodes are commonly affected in this condition.

While lung cancer and non-Hodgkin lymphoma can also present with lymphadenopathy, they typically have different accompanying symptoms or patterns of involvement. A viral infection may cause similar systemic symptoms; however, the specific combination seen in this patient is more indicative of Hodgkin lymphoma, reinforcing its likelihood as the underlying condition.